Nicotine is an agonist of nicotinic receptors in the peripheral and central nervous system, has a pronounced effect on the central nervous system and the cardiovascular system.
Abrupt smoking cessation causes the development of a characteristic withdrawal syndrome, including cravings for smoking.
Clinical studies have shown that nicotine replacement therapy drugs allow smokers to abstain from smoking, alleviating "withdrawal" symptoms. A single dose study in 200 healthy smokers showed that when using 2 doses of 1 mg spray, the urge to smoke decreased from the first minute after using the spray and to a significantly greater extent than when using lozenges containing nicotine. Compared to nicotine gum chews or lozenges, the absorption of nicotine from a topical spray is faster and, based on experience with nicotine replacement therapy, results in a faster reduction in cravings and other symptoms.
Increased appetite is a well-known symptom of nicotine withdrawal, often after smoking cessation, weight gain occurs. The urge to smoke is also an important withdrawal symptom.