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Fipronil is an insecticide and an acaricide belonging to the phenylpyrazole group. It interacts with ligand chloride channels, especially those regulated by the neurotransmitter gamma aminobutyric acid (GABA), thereby blocking the pre- and postsynaptic transfer of chloride ions across cell membranes. This causes uncontrolled activity and death of the central nervous system in insects and ticks. Fipronil kills fleas within 24 hours, ticks (Dermacentor variablis, Dermacentor reticulatus, Rhipicephalus sanguineus, Ixodes ricinus) and lice 48 hours after application.
-methoprene is an insect growth regulator (IAR), a class of compounds known as juvenile hormone analogues that arrest insect development at one stage of development. This substance acts in a similar way to juvenile hormones and causes impaired development and death of fleas at all stages of their development. Oocidal exposure of an animal to (S) -methoprene occurs either directly through freshly laid eggs or through the cuticle through adult fleas. (S) -methoprene effectively stops the further development of flea eggs and larvae, which prevents the immediate vicinity of the animals from being contaminated with fleas at various stages of their development.
Registration of veterinary medicinal productsFipronil is an insecticide and an acaricide belonging to the phenylpyrazole group. It interacts with ligand chloride channels, especially those regulated by the neurotransmitter gamma aminobutyric acid (GABA), thereby blocking the pre- and postsynaptic transfer of chloride ions across cell membranes. This causes uncontrolled activity and death of the central nervous system in insects and ticks. Fipronil kills fleas within 24 hours, ticks (Dermacentor variablis, Dermacentor reticulatus, Rhipicephalus sanguineus, Ixodes ricinus) and lice 48 hours after application.
-methoprene is an insect growth regulator (IAR), a class of compounds known as juvenile hormone analogues that arrest insect development at one stage of development. This substance acts in a similar way to juvenile hormones and causes impaired development and death of fleas at all stages of their development. Oocidal exposure of an animal to (S) -methoprene occurs either directly through freshly laid eggs or through the cuticle through adult fleas. (S) -methoprene effectively stops the further development of flea eggs and larvae, which prevents the immediate vicinity of the animals from being contaminated with fleas at various stages of their development.
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