Fillerina is the first dermo-cosmetic filler treatment to be used at home for external application. The product name comes from the filling mechanism of face depressions (wrinkles) and from the plumping mechanism of specific zones (in vivo test) thanks to the action of special Hyaluronic Acids with different molecular weights for a different level of filling on expression lines, age wrinkles, microrelief and areas of the face subject to sagging or emptying (cheekbones, around the oval of the face, lips surface).

FILLER EFFECT
As skin ages, the amount of Hyaluronic Acid gradually decreases, causing imperfections such as age wrinkles, expression lines and a loss of volume (emptying and skin depressions), especially on cheekbones, cheeks and lips.
Fillerina 12HA Densifying-Filler features a patented mix of 12 different Hyaluronic Acid molecules with varying molecular weights and sizes that are especially effective at penetrating the layers of the skin (ex vivo tests with Franz Cells), thus allowing tissues to be filled in and plumped up. The molecular weights of the 12 Hyaluronic Acids with filling effect contained in this formulation range from 400 to 2000000 Dalton, and up to a Crosspolymer molecule, and all of them showed a great penetration capability (ex vivo test).

DENSIFYING EFFECT
Fillerina 12HA Densifying-Filler associates 3 Collagen molecules with different molecular weights (2 000, 12 000 and 300 000 Da) which, by penetrating down to the dermis (ex vivo test with Franz Cells), can promote an increase in the extracellular matrix density and improve the filling effect, in synergy with Hyaluronic Acid molecules.
With chronological ageing also the quantity and quality of Elastin, the protein that builds up elastic fibres, drastically decreases thus threatening skin plasticity and contributing to skin sagging. The formulation associates 2 molecules of Elastin with different molecular weights (1 400 Da and 2 200 Da), which aim at compensating this loss and restore skin elasticity and plasticity.

TRANSDERMIC TECHNOLOGY
The skin is hardly permeable. In order for Fillerina Hyaluronic Acids and functional molecules to penetrate the different cutaneous layers, Labo researchers developed a patented Transdermic Technology based on the very low molecular weight of the active substances. This is the fundamental condition to guarantee their penetration exclusively in the skin layers. It is precisely thanks to this controlled penetration that the active ingredients are really effective. The percentages reported here above refer to the transdermic penetration of the Hyaluronic Acids and of the functional active molecules (Collagens, Elastins), in solution, after 24 hours. Transdermic penetration was made possible by new Labo technology and tested by means of Franz Cells. The difference vs the theoretical value 100% represents the sum of experimental errors in the procedures applied in the study; these differences are considered.
• FOREHEAD WRINKLES
• GLABELLAR WRINKLES
• EYE CONTOUR WRINKLES
• CHEEKBONES VOLUME
• NASO-LABIAL FOLDS
• LIPS VOLUME
• NECK WRINKLES

TREATMENT
Fillerina 12HA Densifying-Filler treatments for at-home use consist in a Densifying-Filler Gel (Bottle No. 1), having a high content of the 12 absorbable hyaluronic acids, and a Nourishing Film (Bottle No. 2), to be used after the Gel. Intensity 3 prevents the first age and facial wrinkles, skin imperfections and changes in texture, small signs of loss of skin firmness.

Graduated precision applicator with truncated tip. Swiss Patent CH 695 412
Fillerina Complex: Swiss Patent CH 705 713. Transdermic Technology: Swiss Patent CH 711 466.
Cosmetic precision applicator: Swiss Patent CH 695 412.

FILLERINA Additional facial skin care